CJC-1295 +DAC: 10MG

£39.99

Purity: ≥ 99%

£39.99

CJC-1295 +DAC: 10MG

Name: CJC-1295 +DAC: 10MG
Brand: Pure Grade Labs
Price: 39.99 GBP
Availability: OutOfStock

£39.99

Purity: ≥ 99%

£39.99

GHRH RECEPTOR SIGNALLING - Natural growth hormone stimulation research

PHARMACOKINETICS - Long-acting compound & absorption research

GH/IGF-1 - Muscle growth & fat loss hormone research

SOMATOTROPH - Growth hormone & pituitary research

CJC-1295 with DAC (Drug Affinity Complex) is a synthetic analogue of growth hormone-releasing hormone (GHRH 1-29) developed by ConjuChem Biotechnologies. It is a 30-amino acid modified version of sermorelin incorporating four amino acid substitutions - D-Ala2, Gln8, Ala15, Leu27 - that confer resistance to proteolytic inactivation by dipeptidyl peptidase IV (DPP-IV), an enzyme that rapidly degrades native GHRH in circulation.

The defining structural feature of CJC-1295 + DAC is the covalent attachment of a Drug Affinity Complex to its C-terminus via a maleimidopropionyl-lysine linker. After subcutaneous injection, this DAC moiety spontaneously forms a covalent bond with circulating serum albumin - extending the peptide's half-life from the 7-minute half-life of native GHRH to an estimated 5.8-8.1 days in humans, approximately matching albumin's own half-life.

A critical nomenclature distinction: CJC-1295 with DAC is not the same compound as "Modified GRF (1-29)" or "CJC-1295 without DAC." The DAC modification is structurally integral and changes the pharmacokinetic profile entirely. Researchers should confirm which form is required for their application before ordering.

Mechanism: Binds GHRH receptors on pituitary somatotroph cells. Covalent albumin binding via DAC moiety extends systemic half-life to 5.8-8.1 days in humans. Preserves pulsatile GH secretion patterns rather than creating constant elevation.

Research Context: Reached Phase II human clinical trials before development was commercially discontinued. Human PK/PD data published in peer-reviewed literature (Teichman et al., 2006; Ionescu & Frohman, 2006). Strongest clinical evidence base among GHRH analogues.

Sequence: H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Nε-maleimidopropionyl)-NH₂

Molecular Formula: C₁₆₅H₂₇₁N₄₇O₄₆

Molecular Weight: 3647.28 g/mol

CAS Number: 863288-34-0

Form: Lyophilised Solid

The following summaries are drawn from peer-reviewed publications and registered clinical trial records. CJC-1295 with DAC has human pharmacokinetic and pharmacodynamic data from Phase II trials - an evidence tier rarely available for research peptides. Pure Grade Labs does not interpret these findings as evidence of efficacy for any therapeutic indication.

Journal of Clinical Endocrinology & Metabolism: Prolonged stimulation of GH and IGF-I secretion by CJC-1295 in healthy adults

Journal of Clinical Endocrinology & Metabolism: Pulsatile GH secretion persists during continuous stimulation by CJC-1295

American Journal of Physiology - Endocrinology & Metabolism: Once-daily CJC-1295 normalises growth and body composition in GHRH knockout mice

References

https://pubmed.ncbi.nlm.nih.gov/16822960/

https://pubmed.ncbi.nlm.nih.gov/19386527/

https://pmc.ncbi.nlm.nih.gov/articles/PMC2787983/

https://pubmed.ncbi.nlm.nih.gov/26771670/

https://pubmed.ncbi.nlm.nih.gov/21204297/

https://pmc.ncbi.nlm.nih.gov/articles/PMC7598090/

https://clinicaltrials.gov/study/NCT00267527

Every batch of CJC-1295 + DAC supplied by Pure Grade Labs is accompanied by a Certificate of Analysis (COA) from an independent third-party analytical laboratory. The COA confirms identity, purity by HPLC, and absence of contaminants. Given the structural complexity of the DAC conjugation, mass spectrometry confirmation of the intact conjugated peptide is included in the batch documentation.

CJC-1295 + DAC is supplied as a lyophilised solid. The DAC maleimidopropionyl linker is reactive and the peptide is hygroscopic - correct handling is critical. The compound should be weighed under dry conditions and reconstituted carefully to avoid disrupting the DAC conjugation. Vigorous agitation during dissolution should be avoided.

Temperature: -20°C Long-term storage. For short-term use (up to 4 weeks), 2-8°C is acceptable.

Light Sensitivity: Light-Sensitive. Store in original opaque vial. Avoid direct UV or prolonged exposure to light.

Shelf Life: 24 Months. Lyophilized, sealed, stored at -20°C. Batch expiry printed on vial label.

Allow the sealed vial to reach room temperature before opening. CJC-1295 + DAC is hygroscopic - minimise air exposure time once the vial is opened.
Use bacteriostatic water (BAC water) as the reconstitution solvent. Add solvent slowly down the inside wall of the vial - do not inject directly onto the lyophilised cake.
Gently swirl - do not vortex or shake vigorously. Agitation can compromise the DAC maleimidopropionyl conjugation and affect peptide integrity.
Once reconstituted, store at 2-8°C. Use within 28 days. Do not freeze reconstituted solution - repeated freeze-thaw cycles degrade the DAC-albumin binding capacity.
Discard if solution appears cloudy, discoloured, or contains particulate matter.

CJC-1295 + DAC supplied by Pure Grade Labs is intended exclusively for in vitro research and laboratory use. Although CJC-1295 reached Phase II clinical trials, commercial development was discontinued and it has not received regulatory approval for human use from the FDA, MHRA, TGA, EMA, or any other authority.

This product is not a drug, medicine, or supplement and must not be used as such.
Pure Grade Labs makes no claims regarding therapeutic or clinical efficacy in humans.
This product must not be administered to humans or animals outside of a licensed research context.
CJC-1295 is classified as a prohibited substance by WADA under S2 Peptide Hormones, Growth Factors, Related Substances and Mimetics. Athletes subject to drug testing should be aware of this classification.
The legal and regulatory status of this compound varies by jurisdiction. Purchasers are solely responsible for verifying compliance with all applicable laws before ordering.

All product information, research summaries, and study citations presented on this page are provided for informational context only and do not constitute medical advice, endorsement of any treatment, or recommendation for human use.