Longevity & Anti-Ageing

Longevity Research Peptides for Sale UK | Anti-Ageing & Cellular Research Overview

This collection covers the most studied research peptides in the cellular ageing literature — compounds used in laboratory investigations of telomere biology, cellular senescence, mitochondrial signalling, and gene expression in ageing models. Every compound is supplied strictly as a research chemical for laboratory investigation.

Published research in this field targets several distinct hallmarks of ageing: telomere shortening (studied with Epithalon), senescent cell accumulation (studied with FOXO4-DRI), mitochondrial signalling decline (studied with MOTS-c), and age-related shifts in gene expression (studied with GHK-Cu). Each compound is a research tool for a different mechanistic pathway.

Every vial is tested to ≥98% HPLC purity by an independent laboratory before dispatch, with identity confirmed by mass spectrometry. Batch-specific COA on every order.

Sold for research use only. Not for human consumption. No medical claims.

Cellular Ageing Research — Mechanistic Overview

In the published cellular ageing literature, four mechanisms recur as focal points of research:

• Telomere shortening — Epithalon is investigated in laboratory models for effects on telomerase activation and telomere length in ageing cell studies
• Cellular senescence — FOXO4-DRI is investigated in preclinical models for selective clearance of senescent (SASP-producing) cells
• Mitochondrial signalling decline — MOTS-c is a mitochondrial-derived peptide investigated in age-related metabolic decline research
• Age-related gene expression shifts — GHK-Cu is investigated in genomic studies for effects on gene expression profiles of aged fibroblasts

The compounds in this collection are the reference research tools for each of these mechanistic pathways.

Epithalon — Research Overview

Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Professor Vladimir Khavinson and colleagues. In published research it has been studied in cell and animal models for effects on telomerase activity, telomere length, and pineal-gland signalling — with a publication trail of over 30 years across independent Russian and international laboratories.

In telomere biology research, telomerase is the enzyme responsible for extending the repeated DNA sequences at chromosome ends. Loss of telomere length is a widely studied hallmark of cellular ageing. Epithalon is the reference research compound for investigating telomerase-pathway activation in ageing cell studies.

• Telomerase-pathway research — the most documented mechanism in the published Epithalon literature; cell and animal studies investigate telomere-length endpoints
• Cellular ageing marker research in animal models — published studies report changes in oxidative-stress and ageing-marker endpoints in aged rodent models
• Pineal-gland pathway research — original Khavinson research programme investigating pineal signalling in ageing models
• Circadian rhythm research in aged animals — published studies investigate age-related circadian rhythm changes
• Lifespan endpoint studies in rodents — several published animal studies report survival endpoints in aged rodent cohorts
• 30+ years of published research — the longest publication trail of any research peptide in the longevity field

Supplied as a 10mg freeze-dried research vial, ≥98% HPLC purity, certificate of analysis included.

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GHK-Cu — Research Overview

GHK-Cu is a naturally occurring copper-binding tripeptide (Gly-His-Lys) present in human plasma. In published research it declines with chronological age in mammalian studies. Genomic investigations report modulation of expression across a broad panel of human genes in fibroblast studies — cited in the literature as approximately 4,000 gene targets.

GHK-Cu is a reference research compound in fibroblast and skin-cell biology, and in transcriptomic studies of age-related gene expression shifts.

• Broad gene-expression research — cited in the literature as modulating expression of approximately 4,000 human genes in fibroblast studies
• Extracellular matrix protein research — cell studies investigate effects on collagen and elastin gene expression in fibroblast lines
• DNA repair gene pathway research — genomic studies report modulation of DNA repair gene expression
• Anti-inflammatory pathway research — cell studies investigate modulation of inflammatory gene expression in aged tissue models
• Age-related transcriptomic reversion research — the most cited finding in the GHK-Cu literature: shift of aged-fibroblast gene profiles toward younger-fibroblast patterns in cell studies
• Copper-binding biochemistry research — as a copper carrier, used in research investigating copper-dependent enzymatic pathways

Supplied as a 50mg freeze-dried research vial, ≥98% HPLC purity, certificate of analysis included.

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MOTS-c — Research Overview

MOTS-c (Mitochondrial Open Reading frame of the Twelve S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial genome. First characterised in 2015, it is investigated in published research as a mitochondrial-to-nuclear signalling molecule with reported effects on metabolic regulation and gene expression under stress conditions in cell and animal models.

Published research documents age-related decline in circulating MOTS-c levels (Nature Aging, 2021), making it a research reference for age-related mitochondrial signalling.

• Mitochondrial-derived peptide research — reference compound for the mitochondrial-derived peptide (MDP) class
• Age-related decline documented in Nature Aging 2021 — cited as a published age-decline reference in the ageing research literature
• Metabolic regulation research in animal models — published studies investigate metabolic endpoints in aged rodent supplementation experiments
• Nuclear translocation and gene-regulation research — cell studies investigate stress-induced nuclear translocation and transcriptional effects
• Exercise-adaptation pathway research — published studies investigate overlap with exercise-related metabolic signalling pathways
• Emerging research field — one of the newer areas of longevity research, with active publication

Supplied as a 10mg freeze-dried research vial, ≥98% HPLC purity, certificate of analysis included.

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FOXO4-DRI — Research Overview

FOXO4-DRI is a D-retro-inverso (DRI) peptide designed to disrupt the FOXO4–p53 interaction that stabilises senescent cells. It was published in Cell (Baar et al., 2017) as a senolytic research compound — a tool for selectively clearing senescent cells while sparing healthy cells in preclinical models.

Senescent cells accumulate with age and contribute to age-related tissue dysfunction through the senescence-associated secretory phenotype (SASP). FOXO4-DRI is one of the most cited research compounds in the senolytic literature.

Supplied as a 10mg freeze-dried research vial, ≥98% HPLC purity, certificate of analysis included.

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5-Amino-1MQ and AICAR — Research Overview

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT consumes NAD+ precursors, and inhibition is investigated in research as a mechanism for preserving cellular NAD+ pools that decline with age. Used as a research tool in NAD+ and sirtuin-pathway studies.

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AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a small-molecule AMPK activator widely used in research as a tool for investigating the AMPK signalling pathway — the master cellular energy sensor. Studied in laboratory models for effects on mitochondrial biogenesis, metabolic regulation, and pathways overlapping with caloric restriction and exercise biology.

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Longevity Research Stack — Epithalon + GHK-Cu + MOTS-c

The Longevity Research Stack pairs three research compounds targeting three distinct mechanistic pathways in cellular ageing research — telomerase (Epithalon), age-related gene expression (GHK-Cu), and mitochondrial-derived signalling (MOTS-c).

Supplied at a lower combined price than the individual vials. Every vial meets the same ≥98% HPLC purity standard, with COA included on every order.

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Common Research Questions

What are longevity peptides in the research context?

Longevity or "anti-ageing" research peptides are tool compounds used in laboratory investigations of the biological hallmarks of ageing — telomere maintenance, cellular senescence, mitochondrial signalling, and gene-expression shifts. They are not sold as anti-ageing products.

What is a senolytic research compound?

Senolytic research compounds selectively clear senescent cells in preclinical models. FOXO4-DRI is one of the most published senolytic peptides in the literature — cited from the landmark 2017 Cell paper.

What are mitochondrial-derived peptides (MDPs)?

MDPs are short peptides encoded within the mitochondrial genome. MOTS-c is one of the earliest-discovered MDPs (2015) and one of the most studied in ageing research.

What is telomerase and why is it studied in ageing research?

Telomerase is the enzyme responsible for extending telomere sequences at chromosome ends. Loss of telomere length is a widely studied hallmark of cellular ageing, and telomerase-pathway research is a central area of longevity science. Epithalon is the reference research peptide for this pathway.

Why Buy Research Peptides from Pure Grade Labs

• ✓  ≥98% purity — tested by an independent lab before every dispatch
• ✓  Certificate of analysis included — scan the QR code on the vial to verify instantly
• ✓  Identity confirmed by mass spectrometry — every batch, no exceptions
• ✓  UK supply — fast domestic dispatch for laboratory customers
• ✓  Bacteriostatic water available separately — for laboratory reconstitution