Epithalon: 10MG

£14.99

Purity: ≥ 99%

£14.99

Epithalon: 10MG

Name: Epithalon: 10MG
Brand: Pure Grade Labs
Price: 14.99 GBP
Availability: OutOfStock

£14.99

Purity: ≥ 99%

£14.99

TELOMERE - Cellular ageing & lifespan extension research

CIRCADIAN - Sleep quality & hormonal rhythm research

ANTIOXIDANT - Cell damage protection & oxidative stress research

GERONTOLOGY - Healthy ageing & longevity biomarker research

Epithalon (also rendered as Epitalon or Epithalone) is a synthetic tetrapeptide consisting of four amino acids: alanine, glutamic acid, aspartic acid, and glycine (sequence: Ala-Glu-Asp-Gly). It was derived from Epithalamin, a crude polypeptide extract obtained from the bovine pineal gland, and developed through research led by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology beginning in the 1980s. The synthetic peptide was confirmed to be present in physiological pineal gland extract for the first time in 2017, establishing its natural origin.

Over the subsequent 25 years, Epithalon has been evaluated across a substantial body of in vitro, in vivo, and in silico studies, as well as clinical trials focused primarily on gerontological outcomes. Research has concentrated on its reported influence on telomerase activation, circadian rhythm regulation via melatonin pathways, antioxidant defence, and neuroendocrine modulation. It remains one of the most extensively studied synthetic bioregulatory tetrapeptides in the gerontology literature.

Origin: Derived from Epithalamin, a polypeptide extract of the bovine pineal gland. The synthetic sequence replicates the active tetrapeptide fragment (AEDG) identified as responsible for the parent extract's bioregulatory properties.

Research Context: Studied in cell cultures, animal models, and clinical cohorts, primarily in a gerontological context. Research spans telomere biology, circadian regulation, immune function, and antioxidant pathways. Human clinical data exists but is predominantly from Russian research institutions.

Amino Acid Sequence (AEDG): H-Ala-Glu-Asp-Gly-OH

Molecular Formula: C14H22N4O9

Molecular Weight: 390.35g/mol

CAS Number: 307297-39-8

Form: Lyophilised Solid

The following summaries are drawn from peer-reviewed publications and indexed clinical research. Pure Grade Labs does not interpret these findings as evidence of efficacy in humans for any therapeutic purpose.

Bulletin of Experimental Biology and Medicine: Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells

Neuroendocrinology Letters: Pineal peptide preparation epithalamin increases the lifespan and normalises circadian rhythm in elderly patients

International Journal of Molecular Sciences: Overview of Epitalon - Highly Bioactive Pineal Tetrapeptide with Promising Properties

References

https://pmc.ncbi.nlm.nih.gov/articles/PMC11943447/

https://pmc.ncbi.nlm.nih.gov/articles/PMC12411320/

https://pmc.ncbi.nlm.nih.gov/articles/PMC12356729/

https://pubmed.ncbi.nlm.nih.gov/40141333/

https://pubmed.ncbi.nlm.nih.gov/40908429/

https://pubmed.ncbi.nlm.nih.gov/14501183/

https://pubmed.ncbi.nlm.nih.gov/35413689/

https://pubmed.ncbi.nlm.nih.gov/12964022/

https://pubmed.ncbi.nlm.nih.gov/12937682/

https://pubmed.ncbi.nlm.nih.gov/28976150/

Every batch of Epithalon supplied by Pure Grade Labs is accompanied by a Certificate of Analysis (COA) from an independent third-party analytical laboratory. The COA confirms identity, purity by HPLC, and absence of contaminants. Batch-specific documentation is linked below.

Epithalon is supplied as a lyophilised (freeze-dried) solid. As a tetrapeptide, it has relatively good stability compared to larger peptides, but correct handling remains essential to preserve compound integrity. Follow the specifications below.

Temperature: -20°C Long-term storage. For short-term use (up to 4 weeks), 2-8°C is acceptable.

Light Sensitivity: Light-Sensitive. Store in original opaque vial. Avoid direct UV or prolonged exposure to light.

Shelf Life: 24 Months. Lyophilized, sealed, stored at -20°C. Batch expiry printed on vial label.

Allow the sealed vial to reach room temperature before opening to minimise moisture introduction.
Use bacteriostatic water (BAC water) as the reconstitution solvent. Add solvent slowly down the inside wall of the vial - do not inject directly onto the lyophilised cake.
Gently swirl the vial until fully dissolved. Do not vortex or shake vigorously. Epithalon dissolves readily in aqueous solution.
Once reconstituted, store at 2-8°C. Use within 28 days. Do not freeze reconstituted solution.
Discard if solution appears cloudy, discoloured, or contains particulate matter.

Epithalon supplied by Pure Grade Labs is intended exclusively for in vitro research and laboratory use. This product is not approved for human or veterinary use by any regulatory authority, including the FDA, MHRA, TGA, or EMA.

This product is not a drug, medicine, or supplement and must not be used as such.
Pure Grade Labs makes no claims regarding therapeutic or clinical efficacy in humans.
This product must not be administered to humans or animals outside of a licensed research context.
Epithalamin (the parent polypeptide) is approved in Russia for limited medical applications; the synthetic Epithalon tetrapeptide is not approved for medical use by any regulatory authority outside Russia.
Purchasers are solely responsible for compliance with all applicable laws and regulations in their jurisdiction.

All product information, research summaries, and study citations presented on this page are provided for informational context only and do not constitute medical advice, endorsement of any treatment, or recommendation for human use.