MOTS-C: 10MG

£24.99

Purity: ≥ 99%

£24.99

MOTS-C: 10MG

Name: MOTS-C: 10MG
Brand: Pure Grade Labs
Price: 24.99 GBP
Availability: OutOfStock

£24.99

Purity: ≥ 99%

£24.99

METABOLIC REGULATION - Blood sugar control & insulin sensitivity research

SKELETAL MUSCLE - Muscle growth, endurance & performance research

MITOCHONDRIAL BIOLOGY - Cellular energy production & mitochondrial health research

AGING / LONGEVITY - Healthy ageing & physical decline prevention research

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a 16-amino acid peptide encoded by the mitochondrial genome - specifically within the 12S rRNA gene region of mitochondrial DNA, a location not previously understood to produce bioactive peptides. It was first characterised in 2015 by a research team led by Changhan Lee at the USC Davis School of Gerontology. MOTS-c belongs to a class of compounds known as mitochondrial-derived peptides (MDPs), alongside humanin and SHLP1-6, representing a newly defined category of mitochondrial retrograde signalling molecules.

Unlike nuclear-encoded peptides, MOTS-c is produced within the mitochondria and has been shown to translocate to the nucleus under metabolic or physical stress, where it regulates the expression of stress adaptation-related genes. Its primary signalling pathway involves the Folate-AICAR-AMPK axis - MOTS-c inhibits the folate cycle via methylenetetrahydrofolate dehydrogenase (MTHFD), which triggers AMPK activation as a secondary metabolic response. This mechanism positions MOTS-c as a novel intracellular and endocrine-like metabolic regulator, with documented systemic effects on glucose metabolism, insulin sensitivity, inflammation, and physical performance in preclinical models.

Origin: Encoded within the mitochondrial genome (MT-RNR1 gene). Endogenous MOTS-c levels are elevated by exercise and metabolic stress, and decline measurably with age. Circulating levels in young individuals have been reported to be 11-21% higher than in middle-aged and older populations.

Research Context: Studied primarily in animal models and in vitro systems for its effects on glucose metabolism, insulin resistance, physical performance, aging, and inflammation. No completed human clinical trials have been published as of April 2026. MOTS-c is explicitly banned by WADA beginning in 2024.

Amino Acid Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR)

Molecular Formula: C101H152N28O22S2

Molecular Weight: 2,174.6 g/mol

CAS Number: 1627580-64-6

Form: Lyophilised Solid

The following summaries are drawn from peer-reviewed publications. All studies are preclinical unless otherwise noted. Pure Grade Labs does not interpret these findings as evidence of efficacy in humans.

Cell Metabolism: A mitochondrial microprotein encoded by mitochondrial DNA regulates metabolism and extends healthspan

Nature Aging: MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

Journal of Translational Medicine: Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging

References

https://pmc.ncbi.nlm.nih.gov/articles/PMC9905433/

https://pmc.ncbi.nlm.nih.gov/articles/PMC9854231/

https://pmc.ncbi.nlm.nih.gov/articles/PMC9570330/

https://pmc.ncbi.nlm.nih.gov/articles/PMC9866798/

https://pmc.ncbi.nlm.nih.gov/articles/PMC6640593/

https://pmc.ncbi.nlm.nih.gov/articles/PMC11388074/

https://pmc.ncbi.nlm.nih.gov/articles/PMC12345487/

Every batch of MOTS-c supplied by Pure Grade Labs is accompanied by a Certificate of Analysis (COA) from an independent third-party analytical laboratory. The COA confirms identity, purity by HPLC, and absence of contaminants. Batch-specific documentation is linked below.

MOTS-c is supplied as a lyophilised (freeze-dried) solid. As a larger 16-amino acid peptide containing methionine and tryptophan residues, MOTS-c requires careful handling to prevent oxidative degradation. Follow the specifications below for optimal compound integrity.

Temperature: -20°C Long-term storage. For short-term use (up to 4 weeks), 2-8°C is acceptable.

Light Sensitivity: Light-Sensitive. Store in original opaque vial. Avoid direct UV or prolonged exposure to light.

Shelf Life: 24 Months. Lyophilized, sealed, stored at -20°C. Batch expiry printed on vial label.

Allow the sealed vial to reach room temperature before opening to minimise moisture introduction from condensation.
Use bacteriostatic water (BAC water) as the reconstitution solvent. Add solvent slowly down the inside wall of the vial - do not inject directly onto the lyophilised cake.
Gently swirl the vial until fully dissolved. MOTS-c is water-soluble and dissolves readily at room temperature. Do not vortex or shake vigorously.
Once reconstituted, store at 2-8°C and protect from light. Use within 28 days. Do not freeze reconstituted solution.
Discard if solution appears cloudy, discoloured, or contains particulate matter.

MOTS-c supplied by Pure Grade Labs is intended exclusively for in vitro research and laboratory use. This product is not approved for human or veterinary use by any regulatory authority, including the FDA, MHRA, TGA, or EMA.

This product is not a drug, medicine, or supplement and must not be used as such.
Pure Grade Labs makes no claims regarding therapeutic or clinical efficacy in humans.
This product must not be administered to humans or animals outside of a licensed research context.
MOTS-c is explicitly listed as a prohibited substance under the WADA Prohibited List, effective 2024, under the S2 Peptide Hormones and Related Substances category. Any athlete subject to anti-doping regulations must not use this compound.
No completed human clinical trials for MOTS-c have been published as of April 2026. Long-term safety data in humans does not exist. Reported adverse effects from uncontrolled use include elevated heart rate, injection site reactions, insomnia, and fever.
Purchasers are solely responsible for compliance with all applicable laws and regulations in their jurisdiction.

All product information, research summaries, and study citations presented on this page are provided for informational context only and do not constitute medical advice, endorsement of any treatment, or recommendation for human use.