5-Amino-1MQ: 50mg

£34.99

Purity: ≥ 99%

£34.99

5-Amino-1MQ: 50mg

Name: 5-Amino-1MQ: 50mg
Brand: Pure Grade Labs
Price: 34.99 GBP
Availability: OutOfStock

£34.99

Purity: ≥ 99%

£34.99

METABOLIC: Fat burning & NAD+ optimization research

MITOCHONDRIAL: Energy & cellular performance research

ADIPOSE BIOLOGY: Fat cell reduction & lipogenesis research

MUSCLE: Strength, recovery & muscle growth research

5-Amino-1-Methylquinolinium (5-Amino-1MQ) is a small-molecule research compound developed as a selective inhibitor of nicotinamide N-methyltransferase (NNMT) - an enzyme expressed at high levels in adipose tissue, liver, kidney, brain, and skeletal muscle. Unlike many metabolic research compounds that act on hormone receptors, 5-Amino-1MQ works at the intracellular enzymatic level, making it a mechanistically distinct tool for studying metabolic regulation.

NNMT catalyses the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, generating 1-methylnicotinamide (1-MNA) and depleting SAM in the process. When NNMT activity is elevated - a state associated with obesity and metabolic dysregulation - this process consumes NAD+ precursors and methyl donors, impairing mitochondrial function and promoting adipogenic signalling. 5-Amino-1MQ is distinguished by two key pharmacological properties: high membrane permeability (allowing intracellular access) and high selectivity (it does not significantly inhibit related SAM-dependent methyltransferases), making it a useful research probe for isolating NNMT-specific pathway effects.

Classification:Small-molecule NNMT inhibitor. Not a peptide. Often studied alongside peptide-based metabolic compounds due to overlapping research interests in body composition, adiposity, and energy regulation. Structurally belongs to the 1-methylquinolinium scaffold class.

Research Context: Evidence derives primarily from in vitro cell-based models and rodent studies. Mechanisms studied include NAD+ preservation, SAM regulation, adipocyte lipogenesis suppression, and skeletal muscle performance in aged animal models. Human clinical data does not currently exist for this compound.

Chemical Name: 5-Amino-1-methylquinolinium

Formula: C₁₀H₁₁IN₂

Target : NNMT (EC 2.1.1.1)

Molecular Weight: 286.11 g/mol

CAS Number: 42464-96-0

Form: Powder / Solid

The following summaries are drawn from peer-reviewed publications indexed on PubMed. All studies cited are preclinical (in vitro or animal models) unless otherwise noted. No human clinical trials have been conducted on 5-Amino-1MQ as of April 2026. Pure Grade Labs does not interpret these findings as evidence of efficacy in humans.

Biochemical Pharmacology: 5-Amino-1MQ reverses diet-induced obesity in mice through selective NNMT inhibition

Scientific Reports: NNMT inhibition with 5-Amino-1MQ improves grip strength and endurance beyond exercise training alone in aged mice

PubMed / Gut Microbiome Journal: 5-Amino-1MQ combined with dietary intervention produces distinct adiposity and microbiome outcomes in DIO mice

References

https://pubmed.ncbi.nlm.nih.gov/?term=5-amino-1MQ

https://pubmed.ncbi.nlm.nih.gov/?term=NNMT+inhibitor+obesity

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993481/

https://pubmed.ncbi.nlm.nih.gov/34285714/

https://pubmed.ncbi.nlm.nih.gov/30374202/

https://www.sciencedirect.com/topics/biochemistry/nicotinamide-n-methyltransferase

https://examine.com

Every batch of 5-Amino-1MQ supplied by Pure Grade Labs is accompanied by a Certificate of Analysis (COA) from an independent third-party analytical laboratory. The COA confirms identity, purity by HPLC, and absence of contaminants. Batch-specific documentation is linked below.

5-Amino-1MQ is supplied as a lyophilised (freeze-dried) solid, which maximises stability during transit and long-term storage. Correct handling is essential to preserve compound integrity. Follow the specifications below for optimal results.

Temperature: -20°C Long-term storage. For short-term use (up to 4 weeks), 2-8°C is acceptable.

Light Sensitivity: Light-Sensitive. Store in original opaque vial. Avoid direct UV or prolonged exposure to light.

Shelf Life: 24 Months. Lyophilized, sealed, stored at -20°C. Batch expiry printed on vial label.

Allow sealed container to reach room temperature before opening to avoid condensation introducing moisture to the powder.
5-Amino-1MQ is soluble in DMSO and in aqueous solutions at appropriate pH. Solubility is approximately 50 mg/mL in DMSO and up to 10 mg/mL in water at physiological pH.
For aqueous solutions, warm gently if needed. Ensure complete dissolution before use in any experimental system.
Prepared solutions should be stored at 4°C and used within 7 days. Avoid repeated freeze-thaw cycles of dissolved solutions.
Discard any solution that appears discoloured or contains undissolved particulate matter.

5-Amino-1MQ supplied by Pure Grade Labs is intended exclusively for in vitro research and laboratory use. This product is not approved for human or veterinary use by any regulatory authority, including the FDA, MHRA, TGA, or EMA.

This product is not a drug, medicine, or supplement and must not be used as such.
Pure Grade Labs makes no claims regarding therapeutic or clinical efficacy in humans.
This product must not be administered to humans or animals outside of a licensed research context.
No human safety data exists for 5-Amino-1MQ. All available evidence is from cell culture and rodent studies. Translation of preclinical findings to human outcomes is not established.
The compound is not approved by any regulatory body and its legal status may vary by jurisdiction. Purchasers are responsible for verifying compliance with local regulations.
Purchasers are solely responsible for compliance with all applicable laws and regulations in their jurisdiction.

All product information, research summaries, and study citations presented on this page are provided for informational context only and do not constitute medical advice, endorsement of any treatment, or recommendation for human use.