AICAR: 50MG

£34.99

Purity: ≥ 99%

£34.99

AICAR: 50MG

Name: AICAR: 50MG
Brand: Pure Grade Labs
Price: 34.99 GBP
Availability: OutOfStock

£34.99

Purity: ≥ 99%

£34.99

ENERGY METABOLISM - Energy levels & cellular fuel research

ENDURANCE - Stamina, output & aerobic capacity research

METABOLIC - Blood sugar & fat metabolism research

CARDIAC - Heart protection & cardiovascular health research

AICAR (5-Aminoimidazole-4-Carboxamide Ribonucleoside), also known as Acadesine, is a naturally occurring nucleoside intermediate in the purine biosynthesis pathway. It is taken up into cells via adenosine transporters and phosphorylated by adenosine kinase to generate ZMP (AICAR monophosphate) - a structural analogue of AMP that directly activates AMP-activated protein kinase (AMPK) by binding to the regulatory gamma subunit at site 3. This mechanism distinguishes AICAR from many AMPK activators that work indirectly by inhibiting mitochondrial function and altering the cellular AMP:ATP ratio.

AMPK functions as a cellular energy sensor. When activated, it switches off anabolic (energy-consuming) processes and switches on catabolic (energy-producing) pathways - inhibiting lipogenesis and fatty acid synthesis while promoting fat oxidation, glucose uptake, and mitochondrial biogenesis. AICAR's ability to pharmacologically recapitulate aspects of this exercise-induced signalling state has made it one of the most extensively used research tools in metabolic biology. It has been studied in clinical settings for cardiac protection, and its endurance-mimicking properties were sufficiently well-established that it was banned by WADA before any formal doping cases were confirmed.

Mechanism: Converted intracellularly to ZMP, which binds the AMPK gamma subunit and activates AMPK. Unlike mitochondrial inhibitors (e.g. metformin), AICAR activates AMPK without directly altering oxygen uptake or the cellular AMP:ATP ratio, allowing more mechanistically specific AMPK research.

Research Context: One of the most widely studied AMPK activators in the literature. Evidence spans rodent models, in vitro systems, and limited human clinical trials (primarily in cardiac contexts). The compound's exercise-mimetic properties are well-documented preclinically but have not been established in controlled human performance trials.

IUPAC Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-amino-1H-imidazole-4-carboxamide

Primary Target: AMPK (via ZMP)

Molecular Weight: 258.23 g/mol

CAS Number: 2627-69-2

Form: Lyophilised Solid

The following summaries are drawn from peer-reviewed publications indexed on PubMed. AICAR has an unusually broad and deep research literature spanning several decades. The majority of metabolic and performance-related evidence is derived from rodent models. Limited human clinical data exists, primarily from cardiac and metabolic disease contexts. Pure Grade Labs does not interpret these findings as evidence of efficacy in humans for performance or body composition purposes.

Journal of Lipid Research: Chronic AICAR-induced AMPK activation reduces visceral and subcutaneous adiposity and increases leptin sensitivity in rats

Diabetes: Long-term AICAR administration normalises glucose tolerance, improves lipid profile, and lowers blood pressure in an insulin-resistant rat model

Cell Journal: AICAR treatment alone increases running endurance by 44% and induces oxidative gene expression in sedentary mice

References

https://pubmed.ncbi.nlm.nih.gov/29155147/

https://pubmed.ncbi.nlm.nih.gov/39161060/

https://pmc.ncbi.nlm.nih.gov/articles/PMC7952898/

https://pubmed.ncbi.nlm.nih.gov/35013352/

https://pubmed.ncbi.nlm.nih.gov/34304009/

https://pmc.ncbi.nlm.nih.gov/articles/PMC8337113/

https://pmc.ncbi.nlm.nih.gov/articles/PMC11196770/

https://pmc.ncbi.nlm.nih.gov/articles/PMC11622326/

https://www.nmn.com/news/new-insights-on-muscle-strength-the-role-of-inhibiting-an-enzyme-that-hinders-nad-synthesis

https://happyhormonesmd.com/wp-content/uploads/2024/12/5-Amino-1MQ.docx.pdf

https://1stoptimal.com/5-amino-1mq-metabolic-health-fat-loss/

Every batch of AICAR supplied by Pure Grade Labs is accompanied by a Certificate of Analysis (COA) from an independent third-party analytical laboratory. The COA confirms identity, purity by HPLC, and absence of contaminants. Batch-specific documentation is linked below.

AICAR is supplied as a lyophilised (freeze-dried) solid. This form ensures compound stability during transit and long-term storage. Correct handling is required to preserve integrity. Follow the specifications below.

Temperature: -20°C Long-term storage. For short-term use (up to 4 weeks), 2-8°C is acceptable.

Light Sensitivity: Light-Sensitive. Store in original opaque vial. Avoid direct UV or prolonged exposure to light.

Shelf Life: 24 Months. Lyophilized, sealed, stored at -20°C. Batch expiry printed on vial label.

Allow the sealed vial to reach room temperature before opening to minimise moisture introduction from condensation.
AICAR is freely soluble in water. Reconstitute with sterile water for injection or PBS (phosphate-buffered saline) as appropriate for the experimental system. Add solvent slowly down the inside wall of the vial.
Gently swirl until fully dissolved. Do not vortex or shake vigorously. AICAR dissolves readily and should not require extended mixing.
Once reconstituted, store at 2-8°C. Use within 14 days. Do not freeze reconstituted solution as this may alter stability.
Discard if solution appears discoloured or contains particulate matter.

AICAR supplied by Pure Grade Labs is intended exclusively for in vitro research and laboratory use. This product is not approved for human or veterinary use by any regulatory authority, including the FDA, MHRA, TGA, or EMA, for any metabolic, performance, or body composition indication.

This product is not a drug, medicine, or supplement and must not be used as such.
Pure Grade Labs makes no claims regarding therapeutic or clinical efficacy in humans.
This product must not be administered to humans or animals outside of a licensed research context.
AICAR (acadesine) is classified by WADA under the S4 Hormone and Metabolic Modulators category and is prohibited in sport both in and out of competition. Athletes subject to drug testing must be aware of this classification.
AICAR has AMPK-independent biological effects beyond those attributed to AMPK activation alone. Researchers should account for this when designing mechanistic studies and attributing outcomes.
Purchasers are solely responsible for compliance with all applicable laws and regulations in their jurisdiction.

All product information, research summaries, and study citations presented on this page are provided for informational context only and do not constitute medical advice, endorsement of any treatment, or recommendation for human use.