GHK-Cu: 50MG

£18.99

Purity: ≥ 99%

£18.99

GHK-Cu: 50MG

Name: GHK-Cu: 50MG
Brand: Pure Grade Labs
Price: 18.99 GBP
Availability: OutOfStock

£18.99

Purity: ≥ 99%

£18.99

EXTRACELLULAR - Collagen & connective tissue research

VASCULAR - Blood flow, vessel growth & circulation research

ANTI-INFLAMMATORY - Inflammation reduction & immune modulation research

GENOMIC REGULATION - Gene expression & epigenetic activity research

GHK-Cu (glycyl-L-histidyl-L-lysine copper(II) complex) is a naturally occurring copper-binding tripeptide first isolated from human plasma albumin by Dr. Loren Pickart in 1973. The GHK tripeptide has exceptionally high affinity for Cu(II) ions, forming a stable chelate complex. It is found naturally in human plasma, saliva, and urine - with plasma concentrations of approximately 200 ng/mL at age 20, declining to approximately 80 ng/mL by age 60.

In its copper-bound form, GHK-Cu has been the subject of over five decades of investigation across wound healing, collagen synthesis, angiogenesis, and anti-inflammatory biology. At the molecular level, the Cu(II) ion is coordinated by the imidazole nitrogen of histidine, the alpha-amino nitrogen of glycine, and the deprotonated amide nitrogen of the glycine-histidine peptide bond - a configuration that gives GHK-Cu one of the highest stability constants (log K = 16.44) among copper-peptide complexes.

A key property distinguishing GHK-Cu from larger peptide compounds is its very small size (3 amino acids, 403.9 g/mol). This allows rapid diffusion through extracellular space and access to cellular receptors across tissue types. Research has documented systemic effects from localised administration, and preclinical models have recorded activity across skin, musculoskeletal, vascular, and neural tissue contexts.

Origin: Isolated from human plasma albumin by Pickart in 1973. GHK sequence is present within collagen and is proposed to be released from the extracellular matrix at sites of tissue injury, functioning as part of a damage-response signalling system.

Research Context: 50+ years of peer-reviewed investigation. Has been evaluated in human clinical trials for wound healing applications (diabetic ulcers, Mohs surgical wounds). Widely used in cosmetic formulations (INCI: Copper Tripeptide-1). Research also spans genomics and neuroprotection.

Tripeptide Sequence & Complex: H-Gly-His-Lys-OH · Cu(II) | Coordination: imidazole-N (His) + alpha-NH₂ (Gly) + amide-N (Gly-His bond)

Molecular Formula: C₁₄H₂₄CuN₆O₄

Molecular Weight: 403.9 g/mol

CAS Number: 49557-75-7

Form: Lyophilised Solid

GHK-Cu has one of the most extensive evidence bases of any research peptide, spanning five decades. The following summaries represent key publications across its primary research domains. Pure Grade Labs does not interpret these findings as evidence of efficacy in humans for any unapproved application.

FEBS Letters: GHK-Cu stimulates collagen synthesis in fibroblast cultures at picomolar to nanomolar concentrations

Archives of Facial Plastic Surgery: GHK-Cu accelerates growth of irradiated fibroblasts and upregulates bFGF and VEGF production

Biomolecules (MDPI): Regenerative and protective actions of GHK-Cu across tissue and organ systems: a comprehensive review

References

https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/

https://pmc.ncbi.nlm.nih.gov/articles/PMC8789089/

https://pmc.ncbi.nlm.nih.gov/articles/PMC5124859/

https://pmc.ncbi.nlm.nih.gov/articles/PMC11135135/

https://pubmed.ncbi.nlm.nih.gov/34733468/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788471/

Every batch of GHK-Cu supplied by Pure Grade Labs is accompanied by a Certificate of Analysis (COA) from an independent third-party analytical laboratory. The COA confirms identity, purity by HPLC, copper content by ICP-MS (confirming 1:1 Cu:GHK molar ratio), and absence of contaminants. Copper content verification is a critical specification parameter for this compound and is included in all batch documentation.

GHK-Cu is supplied as a lyophilised blue solid. The copper chelate complex is sensitive to pH, temperature, and prolonged aqueous exposure - conditions that can cause copper dissociation and compromise the intact complex. For research applications requiring consistent biological activity, solution conditions (pH, ionic strength) and age of reconstituted material should be carefully controlled. GHK-Cu has a short in vivo plasma half-life (approximately 30 minutes) and 95% is excreted rapidly - a pharmacokinetic characteristic relevant to experimental design.

Temperature: -20°C Long-term storage. For short-term use (up to 4 weeks), 2-8°C is acceptable.

Light Sensitivity: Light-Sensitive. Store in original opaque vial. Avoid direct UV or prolonged exposure to light.

Shelf Life: 24 Months. Lyophilized, sealed, stored at -20°C. Batch expiry printed on vial label.

Allow the sealed vial to reach room temperature. GHK-Cu is a blue solid in lyophilised form - this colouration is normal and reflects the copper chelate.
Reconstitute in sterile water or phosphate-buffered saline (PBS) at physiological pH (7.2-7.4). Avoid highly acidic or alkaline solvents which can promote copper dissociation from the complex.
Gently swirl until fully dissolved. GHK-Cu is water-soluble and dissolves readily. Reconstituted solution will have a blue-green tint consistent with the copper complex.
For multi-use research vials, bacteriostatic water may be used. Store reconstituted solution at 2-8°C and use within 14 days. The copper complex is less stable in prolonged aqueous solution than lyophilised form.
Discard if solution becomes colourless (indicating copper dissociation), turbid, or shows visible precipitation.

GHK-Cu supplied by Pure Grade Labs is intended exclusively for in vitro research and laboratory use. Although GHK-Cu has been evaluated in clinical wound healing trials and is used extensively in cosmetic formulations (as Copper Tripeptide-1), the research-grade compound supplied here is not approved for human use as a drug or therapeutic agent by any regulatory authority.

This product is not a drug, medicine, or supplement and must not be used as such.
Pure Grade Labs makes no claims regarding therapeutic or clinical efficacy in humans for any indication beyond what is documented in published wound healing literature.
This product must not be administered to humans or animals outside of a licensed research context.
GHK-Cu is not currently listed as a prohibited substance by WADA. However, purchasers competing in regulated sport should verify current prohibited lists independently, as classifications may change.
Purchasers are solely responsible for compliance with all applicable laws and regulations in their jurisdiction.

All product information, research summaries, and study citations presented on this page are provided for informational context only and do not constitute medical advice, endorsement of any treatment, or recommendation for human use.