TB-500: 10MG

£39.99

Purity: ≥ 99%

£39.99

TB-500: 10MG

Name: TB-500: 10MG
Brand: Pure Grade Labs
Price: 39.99 GBP
Availability: OutOfStock

£39.99

Purity: ≥ 99%

£39.99

CYTOSKELETAL - Cell structure, motility & tissue remodelling research

STRUCTURAL - Muscle, tendon & connective tissue repair research

VASCULAR - Blood vessel growth & circulation research

ANTI-FIBROTIC - Scar reduction & tissue fibrosis research

TB-500 is a synthetic analogue of thymosin beta-4 (Tβ4), a 43-amino acid peptide encoded by the TMSB4X gene that is naturally present throughout the body. Thymosin beta-4 was first isolated in 1966 by Goldstein and White from bovine thymus tissue and has since been the subject of extensive preclinical investigation across tissue repair, angiogenesis, and cellular migration research.

In commercial and research contexts, "TB-500" has been used to refer to both the full 43-amino acid thymosin beta-4 sequence and to the shorter synthetic heptapeptide fragment (LKKTETQ) corresponding to its actin-binding domain at residues 17-23. The full-length 43-amino acid form - CAS 77591-33-4 - is the version most extensively referenced in preclinical regenerative biology literature, and is the form supplied by Pure Grade Labs.

A key mechanistic property of thymosin beta-4 is its systemic distribution following administration. Unlike locally-acting compounds, it circulates and concentrates at sites of active tissue disruption - an attribute that has made it a focus of research into multi-site and remote injury response.

Origin & Design: Thymosin beta-4 was first isolated from bovine thymus tissue in 1966. The synthetic version replicates the endogenous 43-amino acid sequence for use in controlled laboratory and preclinical research settings.

Research Context: Studied primarily in preclinical animal models and cell-culture systems. Evidence spans tissue repair, vascular formation, anti-fibrotic activity, and cytoskeletal signalling. Human clinical data is limited to closely related compound analogues.

Amino Acid Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH

Molecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S

Molecular Weight: 4,963.4 g/mol

CAS Number: 77591-33-4

Form: Lyophilised Solid

The following summaries are drawn from peer-reviewed publications indexed on PubMed. All studies cited are preclinical unless otherwise noted. Pure Grade Labs does not interpret these findings as evidence of efficacy in humans.

FASEB Journal: Thymosin beta-4 accelerates wound healing and angiogenesis in animal models

Annals of the New York Academy of Sciences: Animal studies with thymosin beta-4: tissue repair and regeneration across multiple model systems

Expert Review of Cardiovascular Therapy: Thymosin beta-4: a multi-functional regenerative peptide - basic properties and clinical applications

References

https://pubmed.ncbi.nlm.nih.gov/10469335/

https://pubmed.ncbi.nlm.nih.gov/22074294/

https://pubmed.ncbi.nlm.nih.gov/20536453/

https://pubmed.ncbi.nlm.nih.gov/23050815/

https://pubmed.ncbi.nlm.nih.gov/23084823/

https://pubmed.ncbi.nlm.nih.gov/22962027/

https://pmc.ncbi.nlm.nih.gov/articles/PMC8228050/

https://pmc.ncbi.nlm.nih.gov/articles/PMC3547647/

https://pmc.ncbi.nlm.nih.gov/articles/PMC4733779/

https://pmc.ncbi.nlm.nih.gov/articles/PMC2930015/

Every batch of TB-500 supplied by Pure Grade Labs is accompanied by a Certificate of Analysis (COA) from an independent third-party analytical laboratory. The COA confirms identity, purity by HPLC, and absence of contaminants. Batch-specific documentation is linked below.

TB-500 is supplied as a lyophilised (freeze-dried) solid, which maximises stability during transit and long-term storage. As a 43-amino acid peptide, TB-500 is sensitive to temperature, moisture, and light degradation. Correct handling is essential to preserve compound integrity. Follow the specifications below.

Temperature: -20°C Long-term storage. For short-term use (up to 4 weeks), 2-8°C is acceptable.

Light Sensitivity: Light-Sensitive. Store in original opaque vial. Avoid direct UV or prolonged exposure to light.

Shelf Life: 24 Months. Lyophilized, sealed, stored at -20°C. Batch expiry printed on vial label.

Allow the sealed vial to reach room temperature before opening to minimise moisture introduction.
Use bacteriostatic water (BAC water) as the reconstitution solvent. Add solvent slowly down the inside wall of the vial - do not inject directly onto the lyophilised cake.
Gently swirl the vial until fully dissolved. Do not vortex or shake vigorously. TB-500 is a large peptide and may take slightly longer to dissolve than smaller sequences.
Once reconstituted, store at 2-8°C. Use within 28 days. Do not freeze reconstituted solution.
Discard if solution appears cloudy, discoloured, or contains particulate matter after full dissolution attempt.

TB-500 (Thymosin Beta-4) supplied by Pure Grade Labs is intended exclusively for in vitro research and laboratory use. This product is not approved for human or veterinary use by any regulatory authority, including the FDA, MHRA, TGA, or EMA.

This product is not a drug, medicine, or supplement and must not be used as such.
Pure Grade Labs makes no claims regarding therapeutic or clinical efficacy in humans.
This product must not be administered to humans or animals outside of a licensed research context.
TB-500 is classified as a prohibited substance by the World Anti-Doping Agency (WADA) under the S2 Peptide Hormones, Growth Factors, Related Substances and Mimetics category. Athletes subject to drug testing should be aware of this classification.
TB-500 is classified as a prescription medicine in some jurisdictions, including Australia and New Zealand. Purchasers are solely responsible for compliance with all applicable laws and regulations in their jurisdiction.
Purchasers must verify the legal status of this compound in their country before placing an order.

All product information, research summaries, and study citations presented on this page are provided for informational context only and do not constitute medical advice, endorsement of any treatment, or recommendation for human use.