Tesamorelin: 5MG

£27.99

Purity: ≥ 99%

£27.99

Tesamorelin: 5MG

Name: Tesamorelin: 5MG
Brand: Pure Grade Labs
Price: 27.99 GBP
Availability: OutOfStock

£27.99

Purity: ≥ 99%

£27.99

METABOLIC - Visceral fat & adipose tissue reduction research

BODY COMPOSITION - Muscle mass, density & physique research

HEPATIC - Liver fat reduction & inflammation research

ENDOCRINE - GH & IGF-1 hormonal optimisation research

Tesamorelin is a synthetic 44 amino acid polypeptide analogue of endogenous growth hormone releasing hormone (GHRH). Its N-terminal trans-3-hexenoic acid modification improves stability and pharmacokinetics relative to native GHRH, extending its half-life in biological environments. Unlike direct exogenous growth hormone administration, tesamorelin acts upstream at the pituitary gland, stimulating the body's own GH secretion in a physiologically pulsatile pattern.

Tesamorelin is one of the few research peptides that has progressed through full FDA Phase III clinical trials, receiving approval in 2010 under the brand name EGRIFTA for a specific medical indication. This regulatory pathway generated a substantial body of high-quality human clinical data - an unusually strong evidence base compared to most research peptides. Its primary studied mechanism involves stimulation of pituitary GH release, subsequent elevation of IGF-1, and preferential reduction of visceral adipose tissue without equivalent changes to subcutaneous fat depots.

Origin & Design: Synthetic analogue of endogenous GHRH (residues 1-44). The trans-3-hexenoic acid modification at the N-terminus confers greater metabolic stability than native GHRH while preserving full receptor binding activity at the pituitary GHRH receptor.

Research Context: Studied in multiple large, randomised, placebo-controlled human trials (n=816 in pooled Phase III analysis). Evidence base is among the strongest of any research peptide, spanning visceral fat reduction, muscle composition, liver fat, and cognitive function.

Structural Modification: trans-3-Hexenoic acid - Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH²

Peptide Length: 44 Amino Acids

Molecular Weight: 5,135.8 g/mol

CAS Number: 218949-48-9

Form: Lyophilised Solid

The following summaries are drawn from peer-reviewed publications indexed on PubMed. Tesamorelin's evidence base is notable for including large-scale, randomised, double-blind, placebo-controlled human trials - a higher standard of evidence than most research peptides. Pure Grade Labs does not interpret these findings as evidence of efficacy in humans outside the studied populations.

Journal of Clinical Endocrinology & Metabolism: Pooled Phase III analysis: tesamorelin reduces visceral adipose tissue in 816 subjects over 52 weeks

Journal of Acquired Immune Deficiency Syndromes: Tesamorelin increases skeletal muscle area and density: secondary analysis of two RCTs (n=341)

JAMA: Tesamorelin reduces visceral and hepatic fat in a 6-month randomised clinical trial (n=48)

References

https://pubmed.ncbi.nlm.nih.gov/20554713/

https://pubmed.ncbi.nlm.nih.gov/31611038/

https://pubmed.ncbi.nlm.nih.gov/25038357/

https://pubmed.ncbi.nlm.nih.gov/28617838/

https://pubmed.ncbi.nlm.nih.gov/18690162/

https://pmc.ncbi.nlm.nih.gov/articles/PMC8243807/

https://pmc.ncbi.nlm.nih.gov/articles/PMC6981288/

https://pmc.ncbi.nlm.nih.gov/articles/PMC6766405/

https://pmc.ncbi.nlm.nih.gov/articles/PMC4363137/

https://pmc.ncbi.nlm.nih.gov/articles/PMC3673013/

Every batch of Tesamorelin supplied by Pure Grade Labs is accompanied by a Certificate of Analysis (COA) from an independent third-party analytical laboratory. The COA confirms identity, purity by HPLC, and absence of contaminants. Batch-specific documentation is linked below.

Tesamorelin is supplied as a lyophilised (freeze-dried) solid. This form maximises compound stability during transit and long-term storage. Correct handling is essential to preserve peptide integrity. Follow the specifications below for optimal results.

Temperature: -20°C Long-term storage. For short-term use (up to 4 weeks), 2-8°C is acceptable.

Light Sensitivity: Light-Sensitive. Store in original opaque vial. Avoid direct UV or prolonged exposure to light.

Shelf Life: 24 Months. Lyophilized, sealed, stored at -20°C. Batch expiry printed on vial label.

Allow the sealed vial to reach room temperature before opening to minimise moisture introduction.
Use bacteriostatic water (BAC water) as the reconstitution solvent. Add solvent slowly down the inside wall of the vial - do not inject directly onto the lyophilised cake.
Gently swirl the vial until fully dissolved. Do not vortex or shake vigorously. TB-500 is a large peptide and may take slightly longer to dissolve than smaller sequences.
Once reconstituted, store at 2-8°C. Use within 28 days. Do not freeze reconstituted solution.
Discard if solution appears cloudy, discoloured, or contains particulate matter after full dissolution attempt.

Tesamorelin supplied by Pure Grade Labs is intended exclusively for in vitro research and laboratory use. This product is not approved for human or veterinary use by any regulatory authority except as noted for its specific approved indication under the brand name EGRIFTA (tesamorelin injection, for subcutaneous use) in the United States.

This product is not a drug, medicine, or supplement and must not be used as such in any unapproved context.
Pure Grade Labs makes no claims regarding therapeutic or clinical efficacy in humans for any purpose beyond the documented research literature.
This product must not be administered to humans or animals outside of a licensed research or clinical context.
Tesamorelin is a prescription-only medicine in all jurisdictions where it is approved. Purchase and use outside of an approved clinical context may be subject to regulatory restrictions in your jurisdiction.
Use of tesamorelin is prohibited in sport by WADA under the S2 Peptide Hormones, Growth Factors, Related Substances and Mimetics category. Athletes subject to drug testing should be aware of this classification.
Purchasers are solely responsible for compliance with all applicable laws and regulations in their jurisdiction.

All product information, research summaries, and study citations presented on this page are provided for informational context only and do not constitute medical advice, endorsement of any treatment, or recommendation for human use.